HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrazole → Pyrimidine, 4-methoxy-6-methyl-2-(1H-pyrazol-1-yl)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrazole | HCID 1048 | — |
| Reactant | 2-Chloro-4-methoxy-6-methylpyrimidine | HCID 12490571 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Pyrimidine, 4-methoxy-6-methyl-2-(1H-pyrazol-1-yl)- | HCID 10702834 | 54.2% |
Reaction Steps
In anhydrous tetrahydrofuran, 159 mg of 2-chloro-4-methoxy-6-methylpyrimidine was substituted with 68 mg of pyrazole. The reaction mixture was treated according to the procedure of Example 5 to yield 103 mg of 4-methoxy-6-methyl-2-(1-pyrazolyl)pyrimidine, and recrystallized from n-hexane to give a compound having a melting point of 52.5°-53° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04849424 |
| Source dataset | uspto-grants-1989_07 |
| ORD ID | ord-de9026c5d9e146eaa003bca526de86f7 |
| Source note | uspto-grants-1989_07 |