HuagongsheHuagongshe Chemistry Print Report · For research reference only
1H-1,2,4-Triazole → 2-Methoxy-6-methyl-4-(1,2,4-triazol-1-yl)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1H-1,2,4-Triazole | HCID 9257 | — |
| Reactant | 4-Chloro-2-methoxy-6-methylpyrimidine | HCID 13425836 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Methoxy-6-methyl-4-(1,2,4-triazol-1-yl)pyrimidine | HCID 14372325 | 22.5% |
Reaction Steps
In anhydrous tetrahydrofuran, 159 mg of 4-chloro-2-methoxy-6-methylpyrimidine was substituted with 69 mg of 1,2,4-triazole. The reaction mixture was treated according to the procedure of Example 5 to yield 43 mg of 2-methoxy-6-methyl-4-(1,2,4-triazol-1-yl)pyrimidine, recrystallized from n-hexane, having a melting point of 98°-98.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04849424 |
| Source dataset | uspto-grants-1989_07 |
| ORD ID | ord-9d0be6eccf774b7ea75bf2a2c8c4415e |
| Source note | uspto-grants-1989_07 |