HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → 4-chloro-2-(1H-imidazol-1-yl)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | 2,4-Dichloropyrimidine | HCID 77531 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-chloro-2-(1H-imidazol-1-yl)pyrimidine | HCID 10607483 | 22.2% |
Reaction Steps
In anhydrous tetrahydrofuran, 1500 mg of 2,4-dichloropyrimidine was substituted with 680 mg of imidazole. The reaction mixture was treated according to the procedure of Example 5 to yield 401 mg of 4-chloro-2-(1-imidazolyl)pyrimidine recrystallized from a mixture of n-hexane and ethyl acetate, having a melting point of 138°-139° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04849424 |
| Source dataset | uspto-grants-1989_07 |
| ORD ID | ord-ce09086f7efe4b7ea1eefcf1ac714b91 |
| Source note | uspto-grants-1989_07 |