Dicyclohexylcarbodiimide → HCID 14620589, compound

Participants

Reaction Steps

To an ice-chilled solution of 2-[(1,2,3,4-tetrahydro-6,7-dimethoxyisoquinolinyl)methyl]benzeneacetic acid (XIc, Ex. 16) (0.4 g, 1.17 mmole) and 4-dimethylaminopyridine (0.15 g, 1.23 mmol) in dry acetonitrile (45 ml) was added with stirring dicyclohexylcarbodiimide (0.24 g, 1.17 mmole). The resulting mixture was stirred at room temperature for 6 hours, then heated to boiling briefly. When the mixture was cooled to room temperature, there was separated a precipitate which was removed by filtration. The filtrate was concentrated to about 10 ml, and chilled in ice to cause a separation of a precipitate. The precipitate was collected on a filter and recrystallized from ethanol, giving the titled product (0.26 g, 69%) which is identical with that described in Example 15.

Provenance & Evidence