N,N-Diethylethylenediamine → HCID 14502046, compound

HRID 231858Notes

Reaction equation

HRID 231858 reaction equation
[CH2:1]([N:3](CC)[C:4](=[O:24])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[CH:11](O)[C:12]1[CH:17]=[CH:16][C:15]([N:18]([CH2:21][CH3:22])[CH2:19][CH3:20])=[CH:14][CH:13]=1)[CH3:2].[CH2:27]([N:29](CC)[CH2:30][CH2:31]N)[CH3:28]>[Cl-].[Zn+2].[Cl-]>[CH2:27]([N:29]([CH2:30][CH3:31])[CH2:2][CH2:1][N:3]1[CH:11]([C:12]2[CH:13]=[CH:14][C:15]([N:18]([CH2:19][CH3:20])[CH2:21][CH3:22])=[CH:16][CH:17]=2)[C:6]2[C:5](=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:4]1=[O:24])[CH3:28]

Participants

4

Reactant 2

HCID 60993N,N-DiethylethylenediamineHCID 14502045HCID 14502045, compound

Product 1

HCID 14502046HCID 14502046, compound

Reagents, catalysts & solvents 1

HCID 3007855ZincchlorideCatalyst

Procedure

Using 3.54 g of Compound C, 0.15 g of anhydrous zinc chloride and 5 ml of N,N-diethylethylenediamine, the same procedures as in Example 16 were repeated. The crude crystals obtained were crystallized from hexane to give 2.38 g of 2-(2-diethylaminoethyl)-3-(4-diethylaminophenyl)isoindolin-1-one (Compound 19).

Workup

  1. customThe crude crystals obtained
  2. customwere crystallized from hexane

Sources & evidence

ORD record
ord-f0fd9ab8c33549b085ce4a60d99d4b7c
Source dataset
uspto-grants-1989_07
Patent number
US04849441

Reaction notes

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