Acetic Acid → HCID 14502055, compound

Participants

Reaction Steps

To a solution of 2.18 g of Compound 29 in 25 ml of acetic acid was added 5 g of zinc powders activated by washing with 2N-hydrochloride. After heating at reflux for 3.5 hours, the mixture was filtered and concentrated under reduced pressure. To the residue was added 20 ml of water, and pH was adjusted to 7 with 10N-sodium chloride solution. Then, filtration was performed and the mother liquor was concentrated under reduced pressure. The residue was subjected to HP-10 high porous polymer column-column chromatography (eluting solvent, water:methyl alcohol=1:3). A major fraction was concentrated to dryness under reduced pressure to give 1.56 g of 2-[2-(2-diethylaminoethyl)isoindolin-1-on-3-yl]benzoic acid (Compound 27).

Provenance & Evidence