Sulfuric Acid → HCID 14502056, compound

Participants

Reaction Steps

To a solution of 0.53 g of Compound 27 in 5 ml of methyl alcohol was added 0.2 ml of conc. sulfuric acid. After heating at reflux for 2 hours, pH was adjusted to 7 with sodium hydrogencarbonate. The mixture was concentrated under reduced pressure. After 30 ml of water and 30 ml of methylene chloride were added to the residue, pH was adjusted to 12 with 10N-sodium hydroxide solution. After shaking, the aqueous layer was discarded and the organic layer was washed with saturated aqueous sodium chloride solution. After drying over anhydrous sodium sulfate, the organic layer was concentrated under reduced pressure to give 0.14 g of methyl 2-[2-(2-diethylaminoethyl)isoindolin-1-on-3-yl]benzoate (Compound 28).

Provenance & Evidence