Dichloromethane → 4-Fluoro-4-[4-(4-methanesulfonyl-phenoxymethyl)-thiazol-2-yl]-piperidine-1-carboxylic acid tert-butyl ester
Reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11]([c:14]2[s:15][cH:16][c:17]([CH2:19][O:20][c:21]3[cH:22][cH:23][c:24]([S:27](=[O:28])(=[O:29])[CH3:30])[cH:25][cH:26]3)[n:18]2)([OH:31])[CH2:12][CH2:13]1.[CH2:32]([N:33]([S:34]([F:35])([F:36])[F:38])[CH2:37][CH3:39])[CH3:40].[Cl:41][CH2:42][Cl:43]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11]([c:14]2[s:15][cH:16][c:17]([CH2:19][O:20][c:21]3[cH:22][cH:23][c:24]([S:27](=[O:28])(=[O:29])[CH3:30])[cH:25][cH:26]3)[n:18]2)([F:38])[CH2:12][CH2:13]1Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-97fc231dbcd740b0b11118baa734d6fa
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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