HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2,3-Dihydro-1H-pyrrolizine-1,7-dicarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Dimethyl 2,3-dihydro-1H-pyrrolizine-1,7-dicarboxylate | HCID 12795063 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2,3-Dihydro-1H-pyrrolizine-1,7-dicarboxylic acid | HCID 12795082 | 71.7% |
Reaction Conditions
| Temperature | 0 °C |
|---|
Reaction Steps
Dimethyl 2,3-dihydro-1H-pyrrolo[1,2-a]pyrrole-1,7-dicarboxylate (1.26 g, 5 mmol) and sodium hydroxide (1.00 g, 25 mmol) were heated in water (10 mL) at reflux for 1 hour. The resulting solution was cooled to 0° C. and acidified with hydrochloric acid (12M) to pH 1. 2,3-Dihydro-1H-pyrrolo-[1,2-a]pyrrole-1,7-dicarboxylic acid (0.70 g, 71.4% yield) was collected by filtration and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04849526 |
| Source dataset | uspto-grants-1989_07 |
| ORD ID | ord-41a05ff536f94a4a9b86cd1076e8398a |
| Source note | uspto-grants-1989_07 |