Ammonia → HCID 86743242, compound

Participants

Reaction Steps

1N Lithium hydroxide (10 ml.) is added to a solution of the ethyl ester product from part (c) (800 mg., 1.15 mmole) in p-dioxane (10 ml.) and the reaction mixture is worked up according to the procedure of Example 4 part (g) to yield 670 mg. of 1-[(S)-2-[[[1-[[(S)-6-[[(phenylmethoxy)carbonyl]amino]-2-[(cyclopropylcarbonyl)amino]-1-oxohexyl]amino]pentyl]hydroxyhosphinyl]oxy]-1-oxopropyl]-L-proline (isomer B). TLC (silica gel; isopropanol: ammonia:water, 7:2:1) Rf =0.43.

Provenance & Evidence