反应详情

4-Chlorothiophenol (21.6 g) was dissolved in dry acetonitrile (500 ml) and a solution of 4-acetoxybenzoyl chloride (29.7 g) in acetonitrile (50 ml) was added. The mixture was stirred at room temperature whilst pyridine (12.1 ml) was added rapidly dropwise. When the reaction was complete the bulk of the solvents was removed by evaporation in vacuo and the residue partitioned between ethyl acetate and water. The separated organic layer was washed with water and brine, dried over magnesium sulphate, and evaporated to afford the desired thioester as a pale yellow solid (41.0 g).

1. additionwas added rapidly dropwise
2. customwas removed by evaporation in vacuo
3. customthe residue partitioned between ethyl acetate and water
4. washThe separated organic layer was washed with water and brine
5. dry with materialdried over magnesium sulphate
6. customevaporated