Hydrochloric Acid → HCID 86743251, compound

Participants

Reaction Steps

A mixture of 50 g of 4-nitrobenzyl 2-(3(S)-[1(R)-[dimethyl-(2-methylprop-2-yl)silyl]oxyethyl]-4(R)-ethylthioazetidin-2-on-1-yl)-3-(4-{diphenyl[2-methylprop-2-yl]silyloxycarbonyl}phenoxy)-3-trimethylacetylthiopropenoate, 500 ml of tetrahydrofuran and 100 ml of 5.5M hydrochloric acid was stirred at room temperature for 24 hours, and then partitioned between diethyl ether and water. The organic layer was washed with water, and with brine, was dried over anhydrous magnesium sulphate, and evaporated in vacuo. Chromatography of the residue over silica gel, and elution with hexane-ethyl acetate-formic acid mixtures afforded 10.2 g of the title compound.

Provenance & Evidence