Thiophosgene → HCID 20031847, compound

Participants

Reaction Steps

A solution of 187 mg of sodium hydroxide in 5 ml of water was added to a stirred suspension of S-(pentafluorophenyl) 3-(hydroxy)thiobenzoate (1.0 g) in chloroform (10 ml) at -10° C. Thiophosgene (0.36 ml) was added and the solution stirred whilst being allowed to reach room temperature. The chloroform layer was separated, dried over anhydrous calcium chloride and evaporated to leave a reside which was chromatographed on silica gel using ethyl acetate/hexane mixtures as eluant to give 0.61 g of the title compound.

Provenance & Evidence