3-Amino-4-fluorophenol → 2-(4-chloro-2-fluorobenzyl)-N-(2-fluoro-5-hydroxyphenyl)-3-oxobutyramide

HRID 2319835Notes

Reaction equation

HRID 2319835 reaction equation
[C:10]([S:11][C:15]([CH:16]([C:17]([CH3:18])=[O:19])[CH2:20][c:21]1[c:22]([F:28])[cH:23][c:24]([Cl:27])[cH:25][cH:26]1)=[O:29])([CH3:12])([CH3:13])[CH3:14].[NH2:1][c:2]1[cH:3][c:4]([OH:9])[cH:5][cH:6][c:7]1[F:8]>>[NH:1]([c:2]1[cH:3][c:4]([OH:9])[cH:5][cH:6][c:7]1[F:8])[C:15]([CH:16]([C:17]([CH3:18])=[O:19])[CH2:20][c:21]1[c:22]([F:28])[cH:23][c:24]([Cl:27])[cH:25][cH:26]1)=[O:29]

Participants

3

Reactant 2

HCID 135191803-Amino-4-fluorophenolHCID 866314512-(4-chloro-2-fluorobenzyl)-3-oxothiobutyric acid S-tert-butyl Ester

Product 1

HCID 866314522-(4-chloro-2-fluorobenzyl)-N-(2-fluoro-5-hydroxyphenyl)-3-oxobutyramide

Sources & evidence

ORD record
ord-ea9cced6d8b1483096059e2adf6bbf44
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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