Methanol → 2-((4-(Hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-6-methyl-5-phenyl thieno[2,3-d]pyrimidin-4(3H)-one

HRID 2319947Notes

Reaction equation

HRID 2319947 reaction equation
[BH4-:30].[CH3:1][c:2]1[c:3](-[c:24]2[cH:25][cH:26][cH:27][cH:28][cH:29]2)[c:4]2[c:5]([n:6][c:7]([CH2:11][n:12]3[n:13][c:14]([C:19]([F:20])([F:21])[F:22])[c:15]([CH:17]=[O:18])[cH:16]3)[nH:8][c:9]2=[O:10])[s:23]1.[CH3:35][OH:36].[Cl:32][CH2:33][Cl:34].[Na+:31]>>[CH3:1][c:2]1[c:3](-[c:24]2[cH:25][cH:26][cH:27][cH:28][cH:29]2)[c:4]2[c:5]([n:6][c:7]([CH2:11][n:12]3[n:13][c:14]([C:19]([F:20])([F:21])[F:22])[c:15]([CH2:17][OH:18])[cH:16]3)[nH:8][c:9]2=[O:10])[s:23]1

Participants

6

Reactant 5

HCID 887MethanolHCID 923Sodium ionHCID 6344DichloromethaneHCID 28123BorohydrideHCID 866303981-((6-Methyl-4-oxo-5-phenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)methyl)-3-(trifluoromethyl)-1H-pyrazole-4-carbaldehyde

Product 1

HCID 665916232-((4-(Hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-6-methyl-5-phenyl thieno[2,3-d]pyrimidin-4(3H)-one

Sources & evidence

ORD record
ord-67d1ed53b84541ccb733d59303a2e4d7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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