Water → HCID 13823209, compound

Participants

Reaction Steps

40 g of 1-[3-(2-dioxolanyl)-propoxy]-4-(N-piperidinylcarbonyl)-pyrazole in a mixture of 150 ml of tetrahydrofuran, 200 ml of water and 4 ml of concentrated sulfuric acid are refluxed for 8 hours. The mixture is cooled and then saturated with sodium chloride, the phases are separated and the aqueous phase is extracted again with tetrahydrofuran. The combined organic phases are evaporated down, the residue is taken up with methylene chloride, the solution is washed with water and the solvent is evaporated off to give 33 g of the title compound in the form of a viscous oil.

Provenance & Evidence