3-Amino-4-methoxycyclobut-3-ene-1,2-dione → 3-Amino-4-[4-(4-piperidinomethylpyrazol-1-yloxy)-butylamino]-cyclobutene-1,2-dione

HRID 232024Notes

Reaction equation

[N:1]1([CH2:7][C:8]2[CH:9]=[N:10][N:11]([O:13][CH2:14][CH2:15][CH2:16][CH2:17][NH2:18])[CH:12]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:19][C:20]1[C:21](=[O:27])[C:22](=[O:26])[C:23]=1OC>CO>[NH2:19][C:20]1[C:21](=[O:27])[C:22](=[O:26])[C:23]=1[NH:18][CH2:17][CH2:16][CH2:15][CH2:14][O:13][N:11]1[CH:12]=[C:8]([CH2:7][N:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)[CH:9]=[N:10]1

Participants

Conditions

Temperature: 20 °C

Procedure

2.5 g of 4-(4-piperidinomethylpyrazol-1-yloxy)butylamine and 1.2 g of 3-amino-4-methoxycyclobutene-1,2-dione are introduced into 80 ml of methanol, and the mixture is stirred for 12 hours at 20° C. The solid formed is then filtered off under suction.

Workup

customThe solid formed
filtrationis then filtered off under suction

Sources & evidence

ORD record: ord-4e6670852429443a95807524b615052e
Source dataset: uspto-grants-1989_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04851410

Reaction notes

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