2-[(3-NITRO-2-PYRIDINYL)AMINO]ETHANOL → 2-[(3-Aminopyridin-2-yl)amino]ethan-1-ol

Participants

Reaction Steps

2-(2-Hydroxyethylamino)-3-nitropyridine (8.9 g) was dissolved in ethanol (200 ml) and hydrogenated over 5% palladium on charcoal (400 mg) at 50 p.s.i. (3.45 bar) for 21/2 hours. The reaction mixture was filtered and the ethanol removed under reduced pressure, yielding the title compound (4.2 g, 56%) as a dark oil which was used without purification in 1(b) below.

Provenance & Evidence