Acetic Anhydride → HCID 88500510, compound

Participants

Reaction Steps

2-(5-Amino-6-chloro-4-pyrimidinylamino)ethanol (Chem. Pharm. Bull., 1961, 9, 27) (5.71 g, 30.3 mmol) and acetic anhydride (50 ml) were heated together under nitrogen at 120° C. for 20 hours. The excess reagent was removed under reduced pressure and the residue was neutralised with aqueous sodium bicarbionate and extracted with dichloromethane (4×70 ml). The extracts were dried (MgSO4) and concentrated under reduced pressure. The residue was purified by flash chromatography (eluting with ethyl acetate) to give 3-(2-acetoxyethyl)-2-methyl-7-chlorimidazo-[4,5-d]pyrimidine (1.597 g, 21%), as a white solid.

Provenance & Evidence