反应详情

A suspension of 1.4 g (50 mmol) of 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, 1.92 g (7.5 mmol) of [1-methyl-2-oxo-2-[(3-pyrrolidinyl)amino]ethyl]-carbamic acid 1,1-dimethylethyl ester, 1.5 g (15 mmol) of triethylamine and 75 ml of acetonitrile was heated at reflux for five hours. The solvent was removed in vacuo and the residue was partitioned between chloroform/water (250 ml each) and acidified to pH 2.0 at 0° with 6.0M hydrochloric acid. The solid was removed by filtration, washed with water and dried in vacuo to give 2.4 g of the title compound, mp 185°-187°.

1. temperaturewas heated
2. temperatureat reflux for five hours
3. customThe solvent was removed in vacuo
4. customthe residue was partitioned between chloroform/water (250 ml each)
5. customacidified to pH 2.0 at 0° with 6.0M hydrochloric acid
6. customThe solid was removed by filtration
7. washwashed with water
8. customdried in vacuo