Hydrochloric Acid → HCID 14555499, compound

Participants

Reaction Steps

A solution of 14.5 g (25 mmol) of [R-(R*,S*)]-1-cyclopropyl-7-[3-[[2-[[(1,1-dimethylethoxy)carbonyl]amino]-1-oxo-3-phenylpropyl]amino]-1-pyrrolidinyl]-6-fluoro-1,4-dihydro-4-oxo-1,8-napthyridine-3-carboxylic acid, 100 ml of 1.0M hydrochloric acid and 100 ml of ethanol was heated at reflux for three hours. The solution was filtered through a fiber glass pad to clarify and the solvent removed in vacuo. The residue was triturated with 100 ml of ethanol/ether (1:1) and the solid was removed by filtration. After washing with ethanol/ether (2×50 ml-1:1) and ether, the solid was dried in vacuo to give 10.2 g of the title compound, mp 216°-219°.

Provenance & Evidence