Ammonia → HCID 20030990, compound

HRID 232092Notes

Reaction equation

HRID 232092 reaction equation
C[O:2][C:3]([C:5]1[N:6]=[CH:7][N:8]([CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[F:17])[CH:9]=1)=O.[NH3:18]>CO>[F:17][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[CH2:10][N:8]1[CH:9]=[C:5]([C:3]([NH2:18])=[O:2])[N:6]=[CH:7]1

Participants

4

Reactant 2

HCID 222Ammonia2×HCID 54250073HCID 54250073, compound

Product 1

HCID 20030990HCID 20030990, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4.0 g of 1-(o-fluorobenzyl)-imidazole-4-carboxylic acid methyl ester are dissolved in 80 ml of methanol and transferred to an autoclave. 20.0 g of ammonia are introduced under pressure and the whole is heated at 100° for 19 hours. When the excess ammonia has been blown off, the resulting product is filtered off and recrystallised from ethanol. 1-(o-fluorobenzyl)-imidazole-4-carboxamide having a melting point of 204°-205° is obtained.

Workup

  1. temperaturethe whole is heated at 100° for 19 hours
  2. filtrationthe resulting product is filtered off
  3. customrecrystallised from ethanol

Sources & evidence

ORD record
ord-5d36cb385912499d8f34a5e3dc690089
Source dataset
uspto-grants-1989_07
Patent number
US04851424

Reaction notes

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