Dihydrobenzofuran → HCID 70377726, compound

HRID 232096Notes

Reaction equation

[CH3:1][CH:2]1[C:15](=O)O[C:12](=O)[C@@H:4]([NH:5]C(=O)C(F)(F)F)[CH2:3]1.[O:17]1[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[CH2:19][CH2:18]1.CC(C(O)=O)C[C@@H](C(O)=O)N>>[NH2:5][CH:4]1[CH2:12][C:23]2=[CH:22][C:21]3[O:17][CH2:18][CH2:19][C:20]=3[CH:25]=[C:24]2[CH2:15][CH:2]([CH3:1])[CH2:3]1

Participants

Reactant 3

HCID 10329Dihydrobenzofuran

HCID 4409594-Methyl-L-glutamate

HCID 54305428HCID 54305428, compound

Product 1

HCID 70377726HCID 70377726, compound

Procedure

This compound may be prepared by condensing 4-methyl-N-trifluoroacetylglutamic anhydride with 2,3-dihydrobenzofuran according to the process described in Example 2. The synthesis of 4-methylglutamic acid is known (J. Pharm. Scien., (1975), 64, No. 11, p. 1855-1858).

Sources & evidence

ORD record: ord-94d2421cd8b941fe97677e7b892c54a3
Source dataset: uspto-grants-1989_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04851429

Reaction notes

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