反应详情

Stir 300 mg. of the iodide prepared in Examples 2 and 3, 3 ml. acetonitrile 112 mg. 2-mercapto-3-pyridinol and 201 mg. cesium carbonate in a reaction flask overnight at room temperature. Remove the acetonitrile and add methylene chloride. Wash with sodium carbonate solution, water, then brine and dry over sodium sulfate. Remove the solvent then add methylene chloride, heat to dissolve the mixture, add hexane and cool to precipitate the title compound as white crystals.

1. customovernight
2. customat room temperature
3. customRemove the acetonitrile
4. additionadd methylene chloride
5. washWash with sodium carbonate solution, water
6. dry with materialbrine and dry over sodium sulfate
7. customRemove the solvent
8. temperatureadd methylene chloride, heat
9. dissolutionto dissolve the mixture
10. additionadd hexane
11. temperaturecool
12. customto precipitate the title compound as white crystals