1-(4-Bromo-phenyl)-2,2-difluoro-propan-1-ol → 10-[4-(2,2-Difluoro-1-hydroxy-propyl)-phenyl]-1,4-dioxa-10-aza-dispiro[4.2.4.2]tetradecan-9-one
Reaction equation
[Br:16][c:17]1[cH:18][cH:19][c:20]([CH:23]([C:24]([CH3:25])([F:26])[F:27])[OH:28])[cH:21][cH:22]1.[O:1]1[CH2:2][CH2:3][O:4][C:5]12[CH2:6][CH2:7][C:8]1([C:9](=[O:13])[NH:10][CH2:11][CH2:12]1)[CH2:14][CH2:15]2>>[O:1]1[CH2:2][CH2:3][O:4][C:5]12[CH2:6][CH2:7][C:8]1([C:9](=[O:13])[N:10]([c:17]3[cH:18][cH:19][c:20]([CH:23]([C:24]([CH3:25])([F:26])[F:27])[OH:28])[cH:21][cH:22]3)[CH2:11][CH2:12]1)[CH2:14][CH2:15]2Participants
3
Sources & evidence
- ORD record
- ord-041cdc21d1e54c7c8f8259dbbd583e4f
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
Loading…