Chloroform → HCID 86743260, compound

Participants

Reaction Steps

162 mg of (2RS,3S)-3-benzyloxycarbonylamino-2-hydroxy-5-methylhexanoic acid 3,5-dimethylpyrazolide was dissolved in 1 ml of dry dichloromethane, and 102 μl of dihydropyran and 0.8 mg of p-toluenesulfonic acid monohydrate were added thereto. The mixture was stirred at room temperature for 1.5 hours. Then, 10 ml of chloroform was added to the mixture, and the mixture was washed with a 4% sodium hydrogencarbonate and a saturated sodium chloride aqueous solution and dried over anhydrous magnesium sulfate. Then, the solvent was distilled off under reduced pressure to obtain 207 mg of (2RS,3S)-3-benzyloxycarbonylamino-2-(2-tetrahydropyranyloxy)-5-methylhexanoic acid 3,5-dimethylpyrazolide as a colorless oily substance.

Provenance & Evidence