phenyl (3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)carbamate → Pexmetinib
Reaction equation
[C:23]([CH3:24])([CH3:25])([CH3:26])[c:27]1[n:28][n:29](-[c:42]2[cH:43][cH:44][c:45]([CH3:48])[cH:46][cH:47]2)[c:30]([NH:32][C:33]([O:34][c:36]2[cH:37][cH:38][cH:39][cH:40][cH:41]2)=[O:35])[cH:31]1.[NH2:1][CH2:2][c:3]1[c:4]([O:5][c:6]2[cH:7][c:8]3[cH:9][n:10][n:11]([CH2:15][CH2:16][OH:17])[c:12]3[cH:13][cH:14]2)[cH:18][cH:19][c:20]([F:22])[cH:21]1>>[NH:1]([CH2:2][c:3]1[c:4]([O:5][c:6]2[cH:7][c:8]3[cH:9][n:10][n:11]([CH2:15][CH2:16][OH:17])[c:12]3[cH:13][cH:14]2)[cH:18][cH:19][c:20]([F:22])[cH:21]1)[C:33]([NH:32][c:30]1[n:29](-[c:42]2[cH:43][cH:44][c:45]([CH3:48])[cH:46][cH:47]2)[n:28][c:27]([C:23]([CH3:24])([CH3:25])[CH3:26])[cH:31]1)=[O:34]Participants
3
Sources & evidence
- ORD record
- ord-6597e6be56cf45bfa5416554ca004e5f
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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