Ammonia → 8'-Bromo-4'-methyl-3',4'-dihydro-2'H-spiro[1,3-dioxane-2,10'-pyrimido[1,2-a]indole]

HRID 2321326Notes

Reaction equation

HRID 2321326 reaction equation
[Br:1][c:2]1[cH:3][c:4]2[c:5]([cH:6][cH:7]1)[N:8]([CH:17]([CH2:18][C:19]#[N:20])[CH3:21])[C:9](=[O:16])[C:10]21[O:11][CH2:12][CH2:13][CH2:14][O:15]1.[CH3:22][CH2:23][OH:24].[NH3:25]>>[Br:1][c:2]1[cH:3][c:4]2[c:5]([cH:6][cH:7]1)[N:8]1[C:9](=[N:20][CH2:19][CH2:18][CH:17]1[CH3:21])[C:10]21[O:11][CH2:12][CH2:13][CH2:14][O:15]1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 702EthanolHCID 589325593-(5'-Bromo-2'-oxospiro[1,3-dioxane-2,3'-indol]-1'(2'H)-yl)butanenitrile

Product 1

HCID 589325258'-Bromo-4'-methyl-3',4'-dihydro-2'H-spiro[1,3-dioxane-2,10'-pyrimido[1,2-a]indole]

Sources & evidence

ORD record
ord-32939bf9e1f049f8865de9ecf5ede217
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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