HCID 57056538, compound → HCID 57316905, compound

Participants

Reaction Steps

254 mg of 3-[(4S,5S)-3-benzyloxycarbonyl-4-isobutyl-2,2-dimethyloxazolidin-5-yl]-2-[2-(2-tetrahydropyranyloxy)propyl]-2-propenoic acid isobutylamide was dissolved in 3 ml of ethanol. Then, a palladium black catalyst was added thereto, and hydrogen was continuously blown into the solution under atmospheric pressure for 4 hours. Then, the catalyst was filtered off, and a fresh palladium black catalyst was added. Then, hydrogen was continuously brown into the solution for further 4 hours. The catalyst was filtered off, and the reaction solution was concentrated and dried under reduced pressure to obtain 180 mg of (2RS,4S,5S)-5-amino-4-hydroxy-2-[2-(2-tetrahydropyranyloxy)propyl]-7-methyl-octanoic acid isobutylamide as a solid substance.

Provenance & Evidence