HCID 57250374, compound → HCID 57182937, compound

Participants

Reaction Steps

93 mg (Z-isomer) of 3-[(4S,5S)-3-benzyloxycarbonyl-2,2-dimethyl-4-isobutyloxazolidin-5-yl]-2-isopropyl-2-propenoic acid isobutylamide was dissolved in 0.8 ml of ethanol and then hydrogenated by using palladium black at atmospheric pressure. The reaction mixture was subjected to filtration, the solvent of the filtrate was distilled off under reduced pressure to obtain 58 mg of (2RS,4S,5S)-5-amino-4-hydroxy-2-isopropyl-7-methyl-octanoic acid isobutylamide as a colorless oily substance.

Provenance & Evidence