Sodium Hydroxide → HCID 14576176, compound

Participants

Reaction Steps

A solution of 6-[1-(4-nitrophenyl)-1,4,5,6-tetrahydro-3-cyclopentapyrazolyl]hexanoic acid methyl ester (see Example 18) (0.07 g) in methanol (10 ml) was treated with 2N sodium hydroxide (2 ml) and heated at reflux temperature for 45 minutes. The solution was cooled, evaporated, diluted with water and acidified. The precipitate was extracted into ethyl acetate, washed with 5% saline, dried, and evaporated. The residue was filtered through CC-4 silica gel to remove polar impurities, and the 25% ethyl acetate in hexane effluent gave pure title compound, m.p. 131°-132° C., after ethanol-water recrystallization.

Provenance & Evidence