Sodium Hydroxide → HCID 14576242, compound

HRID 232151Notes

Reaction equation

HRID 232151 reaction equation
C[O:2][C:3](=[O:27])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][C:9]1[C:17]2[CH2:16][CH2:15][CH2:14][CH2:13][C:12]=2[N:11]([C:18]2[CH:23]=[CH:22][C:21]([N+:24]([O-:26])=[O:25])=[CH:20][CH:19]=2)[N:10]=1.[OH-].[Na+]>CO>[N+:24]([C:21]1[CH:22]=[CH:23][C:18]([N:11]2[C:12]3[CH2:13][CH2:14][CH2:15][CH2:16][C:17]=3[C:9]([CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][C:3]([OH:27])=[O:2])=[N:10]2)=[CH:19][CH:20]=1)([O-:26])=[O:25]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 14576241HCID 14576241, compound

Product 1

HCID 14576242HCID 14576242, compoundYield 77.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of the compound of Example 63 (0.20 g) in methanol (20 ml) was treated with N sodium hydroxide (7.5 ml) and heated at reflux temperature for 30 minutes. The cooled solution was acidified and the precipitate was crystallized from acetonitrile to yield pure title compound (0.15 g), m.p. 119°-121° C.

Workup

  1. temperatureheated
  2. temperatureat reflux temperature for 30 minutes
  3. customthe precipitate was crystallized from acetonitrile

Sources & evidence

ORD record
ord-e998b1fa00574766ab04b19cb9264bca
Source dataset
uspto-grants-1989_07
Patent number
US04851425

Reaction notes

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