Sodium Hydroxide → HCID 20031064, compound

HRID 232154Notes

Reaction equation

HRID 232154 reaction equation
C([O:3][C:4](=[O:24])[CH:5]([C:8]1[C:16]2[CH2:15][CH2:14][CH2:13][CH2:12][C:11]=2[N:10]([C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)[N:9]=1)[O:6][CH3:7])C.[OH-].[Na+]>CO>[Cl:23][C:20]1[CH:21]=[CH:22][C:17]([N:10]2[C:11]3[CH2:12][CH2:13][CH2:14][CH2:15][C:16]=3[C:8]([CH:5]([O:6][CH3:7])[C:4]([OH:24])=[O:3])=[N:9]2)=[CH:18][CH:19]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 54025086HCID 54025086, compound

Product 1

HCID 20031064HCID 20031064, compoundYield 84.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of the compound of Example 73 (0.75 g) in methanol (15 ml) was treated with N sodium hydroxide (6 ml) and reacted at room temperature for 15 minutes. The solution was concentrated in vacuo, diluted with water, and acidified. The precipitate was filtered to yield the title compound (0.58 g). An analytical sample (m.p. 185°-186° C.) was obtained from methanol-hexane solution.

Workup

  1. customreacted at room temperature for 15 minutes
  2. concentrationThe solution was concentrated in vacuo
  3. additiondiluted with water
  4. filtrationThe precipitate was filtered

Sources & evidence

ORD record
ord-02d93d819a794e018c01ca7eb5408de9
Source dataset
uspto-grants-1989_07
Patent number
US04851425

Reaction notes

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