Trifluoroacetic acid → (2R,3S)-3-amino-4-(3,5-difluorophenyl)-1-[(3-methoxybenzyl)amino]-2-butanol

Participants

Reaction Steps

tert-Butyl (1S, 2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propylcarbamate (VII, EXAMPLE 5, 258 mg, 0.59 mmol) is dissolved in methylene chloride (1 mL) at 20-25°, and trifluoroacetic acid (1 mL) is added with stirring under nitrogen. The mixture is stirred at 20-25° for 1 hr, whereupon the mixture is concentrated under reduced pressure to give the title compound. The title compound is used in the next reaction without further purification.

Provenance & Evidence