Methanol → 6-(((1-(2-(7-methoxy-2-oxoquinoxalin-1(2H)-yl)ethyl)piperidin-4-yl)amino)methyl)-2H-pyrido(3,2-b)(1,4)thiazin-3(4H)-one

HRID 2321624Notes

Reaction equation

HRID 2321624 reaction equation
[C:36]([O:37][BH-:38]([O:39][C:40](=[O:41])[CH3:42])[O:43][C:44](=[O:45])[CH3:46])(=[O:47])[CH3:48].[CH3:50][OH:51].[Cl:52][CH2:53][Cl:54].[NH2:1][CH:2]1[CH2:3][CH2:4][N:5]([CH2:8][CH2:9][n:10]2[c:11](=[O:22])[cH:12][n:13][c:14]3[cH:15][cH:16][c:17]([O:20][CH3:21])[cH:18][c:19]23)[CH2:6][CH2:7]1.[Na+:49].[O:23]=[C:24]1[NH:25][c:26]2[c:27]([cH:30][cH:31][c:32]([CH:34]=[O:35])[n:33]2)[S:28][CH2:29]1>>[NH:1]([CH:2]1[CH2:3][CH2:4][N:5]([CH2:8][CH2:9][n:10]2[c:11](=[O:22])[cH:12][n:13][c:14]3[cH:15][cH:16][c:17]([O:20][CH3:21])[cH:18][c:19]23)[CH2:6][CH2:7]1)[CH2:34][c:32]1[cH:31][cH:30][c:27]2[c:26]([n:33]1)[NH:25][C:24](=[O:23])[CH2:29][S:28]2

Participants

7

Reactant 6

HCID 887MethanolHCID 923Sodium ionHCID 6344DichloromethaneHCID 2724942TriacetoxyborohydrideHCID 115935913-Oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazine-6-carbaldehydeHCID 593978381-[2-(4-Aminopiperidin-1-yl)ethyl]-7-methoxyquinoxalin-2(1H)-one

Product 1

HCID 159825356-(((1-(2-(7-methoxy-2-oxoquinoxalin-1(2H)-yl)ethyl)piperidin-4-yl)amino)methyl)-2H-pyrido(3,2-b)(1,4)thiazin-3(4H)-one

Sources & evidence

ORD record
ord-bf7b9bf4e0124866a915562edacecde6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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