HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetone → 9-methoxy-5-hydroxymethyl-11-methyl-6H-pyrido [4, 3-b] carbazole N-methyl carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | Methyl Isocyanate | HCID 12228 | — |
| Reactant | 6H-Pyrido(4,3-b)carbazole, 5-(hydroxymethyl)-11-methyl- | HCID 355814 | — |
| Reactant | 9-Methoxy-5-hydroxymethyl-11-methyl-6H-pyrido [4,3-b] carbazole | HCID 14576123 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 9-methoxy-5-hydroxymethyl-11-methyl-6H-pyrido [4, 3-b] carbazole N-methyl carbamate | HCID 86743262 | — |
Reaction Steps
The above alcohol 36 was dissolved in dry pyridine and dry acetone and treated with methyl isocyanate as in the case of the carbinol 25. The mixture was stirred until no further alcohol 36 could be detected on thin layer chromatography. The solvents were evaporated and the residual solid was crystallized from ethyl acetate-methanol to give the desired carbamate 37.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04851417 |
| Source dataset | uspto-grants-1989_07 |
| ORD ID | ord-4473e82197a04688a0471ed3a8bee759 |
| Source note | uspto-grants-1989_07 |