HRID232230

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10868

Dicyclohexylcarbodiimide

C13H22N2

HCID14181640

未命名化合物

反应SMILES：COC(CC(=O)C(=O)OCc1ccc([N+](=O)[O-])cc1)C(=O)[O-]

HCID67902313

未命名化合物

PRODUCTS

产物

反应SMILES：COC1CC(C(=O)OCc2ccc([N+](=O)[O-])cc2)(N2OC[C@H](NC(=O)OCc3ccccc3)C2=O)OC1=O

HCID67901861

未命名化合物

收率 47.4%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

In 10 ml of dichloromethane was dissolved 896 mg of Compound (93). To the solution were added 680 mg of (4S)-4-benzyloxycarbonylamino-3-isoxazolidinone and 593 mg of DCC, and the mixture was stirred at room temperature for one hour. Then, precipitating crystals were filtered off, and the solvent was evaporated off. The residue was subjected to a silica gel column chromatography, followed by elution with hexane--ethyl acetate (3:2) to give 723 mg of the subject Compound (94) as an oily product.

WORKUP

后处理

customThen, precipitating crystals
filtrationwere filtered off
customthe solvent was evaporated off
washfollowed by elution with hexane--ethyl acetate (3:2)

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-9f9d8d815f4145bbbbf55d6f45a20a66
来源数据集: uspto-grants-1989_07
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US04851422
来源说明: uspto-grants-1989_07

反应SMILES

[CH3:1][O:2][CH:3]([C:20]([O-:22])=[O:21])[CH2:4][C:5](=O)[C:6]([O:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([N+:16]([O-:18])=[O:17])=[CH:12][CH:11]=1)=[O:7].[CH2:23]([O:30][C:31]([NH:33][C@H:34]1[CH2:38][O:37][NH:36][C:35]1=[O:39])=[O:32])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1.C1CCC(N=C=NC2CCCCC2)CC1>ClCCl>[CH2:23]([O:30][C:31]([NH:33][C@H:34]1[CH2:38][O:37][N:36]([C:5]2([C:6]([O:8][CH2:9][C:10]3[CH:11]=[CH:12][C:13]([N+:16]([O-:18])=[O:17])=[CH:14][CH:15]=3)=[O:7])[CH2:4][CH:3]([O:2][CH3:1])[C:20](=[O:21])[O:22]2)[C:35]1=[O:39])=[O:32])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1