Ethanolamine → tert-Butyl 4-aminomethyl-4-fluoropiperidine-1-carboxylate

HRID 2322418Notes

Reaction equation

HRID 2322418 reaction equation
[NH2:27][CH2:28][CH2:29][OH:30].[O:1]=[C:2]1[N:3]([CH2:12][C:13]2([F:26])[CH2:14][CH2:15][N:16]([C:19](=[O:20])[O:21][C:22]([CH3:23])([CH3:24])[CH3:25])[CH2:17][CH2:18]2)[C:10](=[O:11])[c:5]2[c:4]1[cH:9][cH:8][cH:7][cH:6]2>>[NH2:3][CH2:12][C:13]1([F:26])[CH2:14][CH2:15][N:16]([C:19](=[O:20])[O:21][C:22]([CH3:23])([CH3:24])[CH3:25])[CH2:17][CH2:18]1

Participants

3

Reactant 2

HCID 700EthanolamineHCID 53415317Tert-butyl 4-((1,3-dioxoisoindolin-2-yl)methyl)-4-fluoropiperidine-1-carboxylate

Product 1

HCID 40152119tert-Butyl 4-aminomethyl-4-fluoropiperidine-1-carboxylate

Sources & evidence

ORD record
ord-927a61da83e744f2bc939980f4fdab3a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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