p-Fluoronitrobenzene → HCID 20031389, compound

HRID 232266Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][CH:13]([CH2:16][OH:17])[CH2:12][CH2:11]2)=[CH:4][CH:3]=1.F[C:19]1[CH:24]=[CH:23][C:22]([N+:25]([O-:27])=[O:26])=[CH:21][CH:20]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][CH:13]([CH2:16][O:17][C:19]3[CH:24]=[CH:23][C:22]([N+:25]([O-:27])=[O:26])=[CH:21][CH:20]=3)[CH2:12][CH2:11]2)=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 9590p-Fluoronitrobenzene

HCID 20031395HCID 20031395, compound

Product 1

HCID 20031389HCID 20031389, compound

Procedure

In a manner similar to Preparation 2, react 1-[2-(4-chlorophenyl)ethyl]-4-piperidinemethanol with 1-fluoro4-nitrobenzene to obtain the title compound.

Workup

customIn a manner similar to Preparation 2

Sources & evidence

ORD record: ord-6c9108227f1740de8ad6a1f8214b40f3
Source dataset: uspto-grants-1989_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04851526

Reaction notes

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