Cyclopropanecarboxaldehyde → 1-Cyclopropylmethyl-3-pyrrolidinemethanol

HRID 232290Notes

Reaction equation

[CH:1]1([CH:4]=O)[CH2:3][CH2:2]1.[NH:6]1[CH2:10][CH2:9][CH:8]([CH2:11][OH:12])[CH2:7]1>>[CH:1]1([CH2:4][N:6]2[CH2:10][CH2:9][CH:8]([CH2:11][OH:12])[CH2:7]2)[CH2:3][CH2:2]1

Participants

Reactant 2

HCID 123114Cyclopropanecarboxaldehyde

HCID 13400657(Pyrrolidin-3-yl)methanol

Product 1

HCID 200313991-Cyclopropylmethyl-3-pyrrolidinemethanol

Procedure

In a manner similar to Preparation 8, react cyclopropanecarboxaldehyde with 3-pyrrolidinemethanol to obtain the title compound.

Workup

customIn a manner similar to Preparation 8

Sources & evidence

ORD record: ord-29abeacf7c864732ab9483e349271a65
Source dataset: uspto-grants-1989_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04851526

Reaction notes

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