Hexahydrophthalic anhydride → 2-[[[4-(1H-imidazol-1-yl)phenyl](propyl)amino]carbonyl]cyclohexanecarboxylic acid

HRID 232298Notes

Reaction equation

HRID 232298 reaction equation
[N:1]1([C:6]2[CH:11]=[CH:10][C:9]([NH:12][CH2:13][CH2:14][CH3:15])=[CH:8][CH:7]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.[CH:16]12[C:25](=[O:26])[O:24][C:22](=[O:23])[CH:17]1[CH2:18][CH2:19][CH2:20][CH2:21]2>>[N:1]1([C:6]2[CH:11]=[CH:10][C:9]([N:12]([CH2:13][CH2:14][CH3:15])[C:22]([CH:17]3[CH2:18][CH2:19][CH2:20][CH2:21][CH:16]3[C:25]([OH:24])=[O:26])=[O:23])=[CH:8][CH:7]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

3

Reactant 2

HCID 85689Hexahydrophthalic anhydrideHCID 200313164-(1H-Imidazole-1-yl)-N-propylbenzenamine

Product 1

HCID 145556542-[[[4-(1H-imidazol-1-yl)phenyl](propyl)amino]carbonyl]cyclohexanecarboxylic acid

Procedure

In a manner similar to Preparation 6, react 4-(1H-imidazol-1-yl)-N-propylbenzenamine with 1,2-cyclohexanedicarboxylic acid anhydride to obtain the title compound.

Workup

  1. customIn a manner similar to Preparation 6

Sources & evidence

ORD record
ord-29d43eaa4d1247fc95ded9e0d264e147
Source dataset
uspto-grants-1989_07
Patent number
US04851526

Reaction notes

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