Thionyl Chloride → 2-[[[4-(1H-imidazol-1-yl)phenyl](propyl)amino]-carbonyl]cyclohexanecarbonyl chloride

HRID 232299Notes

Reaction equation

HRID 232299 reaction equation
[N:1]1([C:6]2[CH:11]=[CH:10][C:9]([N:12]([CH2:24][CH2:25][CH3:26])[C:13]([CH:15]3[CH2:20][CH2:19][CH2:18][CH2:17][CH:16]3[C:21](O)=[O:22])=[O:14])=[CH:8][CH:7]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.S(Cl)([Cl:29])=O>>[N:1]1([C:6]2[CH:11]=[CH:10][C:9]([N:12]([CH2:24][CH2:25][CH3:26])[C:13]([CH:15]3[CH2:20][CH2:19][CH2:18][CH2:17][CH:16]3[C:21]([Cl:29])=[O:22])=[O:14])=[CH:8][CH:7]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 145556542-[[[4-(1H-imidazol-1-yl)phenyl](propyl)amino]carbonyl]cyclohexanecarboxylic acid

Product 1

HCID 145556552-[[[4-(1H-imidazol-1-yl)phenyl](propyl)amino]-carbonyl]cyclohexanecarbonyl chloride

Procedure

In a manner similar to Preparation 15, react 2-[[[4-(1H-imidazol-1-yl)phenyl](propyl)amino]carbonyl]cyclohexanecarboxylic acid with thionyl chloride to obtain the title compound.

Workup

  1. customIn a manner similar to Preparation 15

Sources & evidence

ORD record
ord-04dffd5affa14123a7dbd010b6904987
Source dataset
uspto-grants-1989_07
Patent number
US04851526

Reaction notes

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