3-Hydroxyazetidine → 1-[2-(3,4-Dimethoxyphenyl)ethyl]azetidin-3-ol

HRID 232306Notes

Reaction equation

HRID 232306 reaction equation
[NH:1]1[CH2:4][CH:3]([OH:5])[CH2:2]1.Br[CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[C:11]([O:17][CH3:18])[CH:10]=1>>[CH3:18][O:17][C:11]1[CH:10]=[C:9]([CH2:8][CH2:7][N:1]2[CH2:4][CH:3]([OH:5])[CH2:2]2)[CH:14]=[CH:13][C:12]=1[O:15][CH3:16]

Participants

3

Reactant 2

HCID 15142903-HydroxyazetidineHCID 114706023,4-Dimethoxyphenethyl bromide

Product 1

HCID 200313801-[2-(3,4-Dimethoxyphenyl)ethyl]azetidin-3-ol

Procedure

In a manner similar to Preparation 73, react azetidin-3-ol with 1-bromo-2-(3,4-dimethoxyphenyl)ethane to obtain the title compound.

Workup

  1. customIn a manner similar to Preparation 73

Sources & evidence

ORD record
ord-f581dcc50077449698ee1eba14ab64fe
Source dataset
uspto-grants-1989_07
Patent number
US04851526

Reaction notes

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