Sodium hydride → HCID 16794378, compound

Participants

Reaction Steps

Add 5.0 g (30.9 mmol) of 2-trifluoromethylphenol to a 0° C. suspension of 2.72 g (67.9 mmol, 2.2 eq, 60% by wt. in mineral oil) of sodium hydride in 100 mL of dry tetrahydrofuran. Once the 2-trifluoromethylphenol is dissolved add 7.88 g (67.9 mmol, 2.2 eq) of 2-chloroethylamine hydrochloride and stir at room temperature for 18 hr. Concentrate the reaction mixture and partition between 200 mL of methylene chloride and 50 mL water. Dry the organic layer over Na2SO4 and concentrate in vacuo to obtain the title compound.

Provenance & Evidence