N-Ethyl-4-(1H-imidazol-1-yl)benzenamine → 1-[(Cyclopropyl)methyl]-N-ethyl-N-[4-(1H-imidazol-1-yl)-phenyl]-3-pyrrolidinemethanamine

HRID 232319Notes

Reaction equation

HRID 232319 reaction equation
CS(O[CH2:6][CH:7]1[CH2:11][CH2:10][N:9]([CH2:12][CH:13]2[CH2:15][CH2:14]2)[CH2:8]1)(=O)=O.[CH2:16]([NH:18][C:19]1[CH:24]=[CH:23][C:22]([N:25]2[CH:29]=[CH:28][N:27]=[CH:26]2)=[CH:21][CH:20]=1)[CH3:17]>>[CH:13]1([CH2:12][N:9]2[CH2:10][CH2:11][CH:7]([CH2:6][N:18]([CH2:16][CH3:17])[C:19]3[CH:20]=[CH:21][C:22]([N:25]4[CH:29]=[CH:28][N:27]=[CH:26]4)=[CH:23][CH:24]=3)[CH2:8]2)[CH2:15][CH2:14]1

Participants

3

Reactant 2

HCID 14555650N-Ethyl-4-(1H-imidazol-1-yl)benzenamineHCID 20031374HCID 20031374, compound

Product 1

HCID 145556211-[(Cyclopropyl)methyl]-N-ethyl-N-[4-(1H-imidazol-1-yl)-phenyl]-3-pyrrolidinemethanamine

Procedure

In a manner similar to Preparation 2, react 1-cyclopropylmethyl-3-pyrrolidinemethanol methanesulfonate with N-ethyl-4-(1H-imidazol-1-yl)benzenamine to obtain the title compound.

Workup

  1. customIn a manner similar to Preparation 2

Sources & evidence

ORD record
ord-9bdedd26e8ee4932bb8c3616e86d458d
Source dataset
uspto-grants-1989_07
Patent number
US04851526

Reaction notes

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