HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyanoacetic acid → HCID 54086143, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyanoacetic acid | HCID 9740 | — |
| Reactant | Cyclododecanone | HCID 13246 | — |
| Reactant | tetradecahydrocyclododeca[b]furan | HCID 14687820 | — |
| Product | HCID 54086143 | HCID 54086143 | — |
Reaction Steps
13-oxabicyclo[10.3.0]pentadecane, a valuable ambergris fragrance, is prepared by reacting cyclododecanone with cyanoacetic acid in the presence of a Knoevenagel catalyst to form cyclododecenylacetonitrile, the nitrile is hydrolyzed to cyclododecenylacetic acid, and the acid is cyclized to the lactone, and the lactone is reduced to the corresponding diol which is cyclized to 13-oxabicyclo[10.3.0]pentadecane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04851552 |
| Source dataset | uspto-grants-1989_07 |
| ORD ID | ord-6443ebba35f7430bb775b16189d70029 |
| Source note | uspto-grants-1989_07 |