Water → HCID 18633450, compound

Participants

Reaction Steps

A mixture of 6.5 g of 2'-deoxy-5-ethyl-5'-O-trityluridine, 19 g of powdered potassium hydroxide and 9.5 ml of benzyl chloride in a mixture of 60 ml of benzene and 21 ml of dioxane was stirred and heated under reflux for 4 hours. After cooling 65 ml of water and 20 ml of acetic acid were added and the phases were separated. The organic phase was washed twice with 90 ml of water each time, dried over anhydrous sodium sulfate and evaporated to give 4.5 g of 3'-O-benzyl-2'-deoxy-5-ethyl-5'-O-trityluridine in the form of a sticky solid.

Provenance & Evidence