Methanesulfonyl chloride → HCID 13923448, compound

Participants

Reaction Steps

A solution of 16.0 g of 2'-deoxy-5-ethyl-5'-O-trityluridine and 6.8 ml of methanesulfonyl chloride in 140 ml of pyridine was stored at 0° C. overnight. 3 g of ice were added, the mixture was stored at 0° C. for 1 hour and then poured into 1500 ml ice/water. The resulting solid was collected by filtration, washed with 500 ml of water and dried to yield 17.35 g of 2'-deoxy-5-ethyl-3'-O-methanesulfonyl-5'-O-trityluridine in the form of a white solid which was used in the next step without further purification.

Provenance & Evidence