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HRID232370

反应详情

EQUATION

反应方程式

HRID 232370 的结构方程式

REACTANTS

反应物

2
结构：CC(=O)OC(C)=O
HCID7918

Acetic anhydride

C4H6O3

结构：CCc1cn([C@H]2C[C@H](O)[C@@H](CN(C)C(=O)Cc3ccccc3Br)O2)c(=O)[nH]c1=O
HCID18633406

未命名化合物

PRODUCTS

生成物

1
结构：CCc1cn([C@H]2C[C@H](OC(C)=O)[C@@H](CN(C)C(=O)Cc3ccccc3Br)O2)c(=O)[nH]c1=O
HCID18633397

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：c1ccncc1
溶剂HCID1049

Pyridine

C5H5N

PROCEDURE

实验过程

0.05 g of 5'-[2-(2-bromophenyl)-N-methylacetamido]-2',5'-dideoxy-5-ethyluridine was dissolved in 2 ml of dry pyridine and the solution was treated with 0.12 ml of acetic anhydride. The mixture was stirred at room temperature for 5 hours and then evaporated. The residue was re-evaporated with toluene to give a solid which was triturated with diethyl ether and then removed by filtration. There was obtained 0.03 g of 3'-O-acetyl-5'-[2-(2-bromophenyl)-N-methylacet-amido]-2',5'-dideoxy-5-ethyluridine of melting point about 170° C.

WORKUP

后处理

  1. customevaporated
  2. customThe residue was re-evaporated with toluene
  3. customto give a solid which
  4. customwas triturated with diethyl ether
  5. customremoved by filtration