4-(1-Pyrrolidinyl)piperidine → [5-Methyl-3-pyridin-4-yl-1-(3-trifluoromethyl-phenyl)-1H-pyrazol-4-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone

HRID 2323708Notes

Reaction equation

HRID 2323708 reaction equation
[CH3:1][c:2]1[c:3]([C:23](=[O:24])[OH:25])[c:4](-[c:17]2[cH:18][cH:19][n:20][cH:21][cH:22]2)[n:5][n:6]1-[c:7]1[cH:8][c:9]([C:13]([F:14])([F:15])[F:16])[cH:10][cH:11][cH:12]1.[N:26]1([CH:31]2[CH2:32][CH2:33][NH:34][CH2:35][CH2:36]2)[CH2:27][CH2:28][CH2:29][CH2:30]1>>[CH3:1][c:2]1[c:3]([C:23](=[O:24])[N:34]2[CH2:33][CH2:32][CH:31]([N:26]3[CH2:27][CH2:28][CH2:29][CH2:30]3)[CH2:36][CH2:35]2)[c:4](-[c:17]2[cH:18][cH:19][n:20][cH:21][cH:22]2)[n:5][n:6]1-[c:7]1[cH:8][c:9]([C:13]([F:14])([F:15])[F:16])[cH:10][cH:11][cH:12]1

Participants

3

Reactant 2

HCID 787034-(1-Pyrrolidinyl)piperidineHCID 673152345-methyl-3-pyridin-4-yl-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-4-carboxylic acid

Product 1

HCID 57555055[5-Methyl-3-pyridin-4-yl-1-(3-trifluoromethyl-phenyl)-1H-pyrazol-4-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone

Sources & evidence

ORD record
ord-190bfe878ca04f908a113065121a8fa8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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